Description
Mouse S100A13 is an 11kD member of the S100 (soluble in 100% saturated ammonium sulfate) family of vertebrate EF-hand Ca ++ -binding proteins. It is widely expressed as a homodimer with 98 amino acid (aa) long subunits. Mouse S100A13 shares 87%, 83%, 91%, 86%, 81% and 53% aa identity with rat, human, cow, dog, opossum and chicken S100A13, respectively. Like other S100 proteins, S100A13 is small and generally acidic, but it contains a basic residue-rich sequence at the C terminus, and two EF hand motifs that bind Ca++ with differing affinities. Some S100 proteins, including S100A13, are able to bind the cell surface receptor for advanced glycation end-products (RAGE)